09 July 2020 : Laboratory Research
Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 15 (SNHG15) Alleviates Osteoarthritis Progression by Regulation of Extracellular Matrix Homeostasis
Yunping Chen1AB, Hongna Guo1AB, Lang Li23A, Dingsu Bao24B, Feng Gao3C, Qiang Li3D, Qi Huang3D, Xin Duan2F, Zhou Xiang2AG*DOI: 10.12659/MSM.923868
Med Sci Monit 2020; 26:e923868
Figure 2 Low KLF4 expression in human OA knee cartilage tissues and IL-1β-stimulated OA chondrocytes. (A) Comparison of expression levels of KLF4 between human OA and normal cartilage tissues in GSE114007 dataset. (B) qRT-PCR showing KLF4 expression in IL-1β-stimulated chondrocytes. (C) Protein-protein interaction network of KLF4. (D, E) Functional enrichment analysis results of co-expressed proteins of KLF4. (F) qRT-PCR showing the transfection efficiency of KLF4 overexpression or knockdown in chondrocytes. (G) The expression levels of MMP3, ADAMTS5, COL2A1, and Aggrecan in IL-1β-stimulated chondrocytes transfected by KLF4 overexpression as shown by qRT-PCR. * p<0.05; ** p<0.01, *** p<0.001; **** p<0.0001.