09 July 2020 : Laboratory Research
Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 15 (SNHG15) Alleviates Osteoarthritis Progression by Regulation of Extracellular Matrix Homeostasis
Yunping Chen1AB, Hongna Guo1AB, Lang Li23A, Dingsu Bao24B, Feng Gao3C, Qiang Li3D, Qi Huang3D, Xin Duan2F, Zhou Xiang2AG*DOI: 10.12659/MSM.923868
Med Sci Monit 2020; 26:e923868
Figure 7 SNHG15 inhibits β-catenin via miR-7/KLF4 in IL-1β-stimulated chondrocytes. (A, B) β-catenin expression was inhibited by SNHG15 overexpression in IL-1b-stimulated chondrocytes, which was reversed by miR-7 overexpression as shown by Western blot. (C) MiR-7 overexpression reversed the effects of SNHG15 and KLF4 on ECM degradation and chondrocyte formation in IL-1β-stimulated chondrocytes by qRT-PCR. (D) MiR-7 reversed the effects of SNHG15 and KLF4 on β-catenin expression in IL-1β-stimulated chondrocytes by qRT-PCR. * p<0.05, ** p<0.01, **** p<0.0001.