09 July 2020>: Lab/In Vitro Research
Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 15 (SNHG15) Alleviates Osteoarthritis Progression by Regulation of Extracellular Matrix Homeostasis
Yunping Chen 1AB* , Hongna Guo 1AB* , Lang Li 23A , Dingsu Bao 24B , Feng Gao 3C , Qiang Li 3D , Qi Huang 3D , Xin Duan 2F , Zhou Xiang 2AG*DOI: 10.12659/MSM.923868
Med Sci Monit 2020; 26:e923868
Figure 7 SNHG15 inhibits β-catenin via miR-7/KLF4 in IL-1β-stimulated chondrocytes. (A, B) β-catenin expression was inhibited by SNHG15 overexpression in IL-1b-stimulated chondrocytes, which was reversed by miR-7 overexpression as shown by Western blot. (C) MiR-7 overexpression reversed the effects of SNHG15 and KLF4 on ECM degradation and chondrocyte formation in IL-1β-stimulated chondrocytes by qRT-PCR. (D) MiR-7 reversed the effects of SNHG15 and KLF4 on β-catenin expression in IL-1β-stimulated chondrocytes by qRT-PCR. * p<0.05, ** p<0.01, **** p<0.0001.