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28 August 2020: Clinical Research

Circ_cse1l Inhibits Colorectal Cancer Proliferation by Binding to eIF4A3

Bin Xu 1ABCDEF , Ning Yang 1BCDF , Yabin Liu 1BCDF , Peng Kong 2ACE , Mei Han 2AG , Binghui Li 1ABCDEFG*

DOI: 10.12659/MSM.923876

Med Sci Monit 2020; 26:e923876

Figure 3 Overexpression of circ_cse1l inhibits CRC cell proliferation while reducing PCNA expression. HT29 and HCT116 cells were transfected with a circ_cse1l overexpression vector and an empty vector (NC). (A) CCK-8 and (B) colony formation assays, showing that overexpression of circ_cse1l inhibited the proliferation of HT29 and HCT116 cells. (C) Western blotting experiments, showing that circ_cse1l overexpression reduced the expression of PCNA protein in HT29 and HCT116 cells. * P<0.05, ** P<0.01.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750