Pyrazolo[4,3-c]pyridine-4-one (PP-4-one) Exhibits Anti-Epileptogenic Effect in Rat Model of Traumatic Epilepsy by Mammalian Target of Rapamycin (mTOR) Signaling Pathway Downregulation

Jungong Jin; Xi Shen; Lu Tian; Guoyishi He; Ying Zhang

doi:10.12659/MSM.923919

20 July 2020 : Laboratory Research

Pyrazolo[4,3-c]pyridine-4-one (PP-4-one) Exhibits Anti-Epileptogenic Effect in Rat Model of Traumatic Epilepsy by Mammalian Target of Rapamycin (mTOR) Signaling Pathway Downregulation

Jungong Jin^1BCD, Xi Shen^2BCF, Lu Tian^3BCD, Guoyishi He^1BCD, Ying Zhang^3ADEF*

DOI: 10.12659/MSM.923919

Med Sci Monit 2020; 26:e923919

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Figure 2 Effect of PP-4-one on behavioral seizures. The PTE rats treated with or without PP-4-one treatment were subjected to measurement of behavioral seizures. * P<0.02 and ** P<0.02 vs. the vehicle-treated rats.

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Pyrazolo[4,3-c]pyridine-4-one (PP-4-one) Exhibits Anti-Epileptogenic Effect in Rat Model of Traumatic Epilepsy by Mammalian Target of Rapamycin (mTOR) Signaling Pathway Downregulation

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