22 July 2020 : Laboratory Research
Phospholipase Cε Regulates Prostate Cancer Lipid Metabolism and Proliferation by Targeting AMP-Activated Protein Kinase (AMPK)/Sterol Regulatory Element-Binding Protein 1 (SREBP-1) Signaling Pathway
Yongbo Zheng1ABCDEF, Jiajia Jin2ABCDF, Yingying Gao3ACF, Chunli Luo4AG, Xiaohou Wu1AG, Jiayu Liu1ABCDE*DOI: 10.12659/MSM.924328
Med Sci Monit 2020; 26:e924328
Figure 5 Silencing PLCɛ blocks SREBP-1 nuclear translocation. (A) Immunofluorescence staining revealed SREBP-1 intracellular distribution changes in LNCap and PC3 cells. (B–E) Western blot illustrated that silencing PLCɛ observably downregulates SREBP-1 expression in the nucleus but not in the cytoplasm in the 2 PCa cell lines.