30 August 2020>: Lab/In Vitro Research
Asiaticoside Antagonizes Proliferation and Chemotherapeutic Drug Resistance in Hepatocellular Carcinoma (HCC) Cells
Ying Ma BE , Jun Wen BC , Jing Wang CE , Chunyan Wang DF , Yan Zhang DEF , Lili Zhao F , Jia Li A* , Xue Feng FDOI: 10.12659/MSM.924435
Med Sci Monit 2020; 26:e924435
Figure 4 Asiaticoside inhibited PI3K/Akt pathways in QGY-7703 and Bel-7402 cells. (A) Protein bands showed alteration of key proteins in PI3K/Akt pathways after asiaticoside treatment for 48 h in QGY-7703 cells. (B, C) The relative intensity of protein expression of PI3K subunits p110α, p110β, and p110γ, and p-PDK, p-Akt, and p-mTOR after treatment with asiaticoside for 48 h in QGY-7703 cells. (D) Protein bands showed alteration of key proteins in PI3K/Akt pathways after asiaticoside treatment for 48 h in Bel-7402 cells. (E, F) The relative intensity of protein expression of PI3K subunits p110α, p110β, and p110γ, and p-PDK, p-Akt, and p-mTOR after treatment with asiaticoside for 48 h in Bel-7402 cells. Data are presented as mean±SD, which are representative of at least 3 independent experiments.