Figure 2 The results of differential expression genes analysis and functional enrichment analysis between 498 primary PRAD and 52 normal solid tissue. A total of 6005 genes including 2697 downregulated ones and 3308 upregulated ones were identified as DEGs between 498 primary PRAD and 52 normal solid tissue, illustrating in heatmap (A) and volcano plot (B). Most significant GO (C) and KEGG (D) terms for DEG were muscle system process, collagen–containing extracellular matrix, passive transmembrane transporter activity, and neuroactive ligand–receptor interaction, illustrating in bubble plot. PRAD – prostate adenocarcinoma; DEGs – differential expressed genes; GO – Gene Ontology; KEGG – Kyoto Encyclopedia of Genes and Genomes.