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22 August 2020: Animal Study

Role of Sirtuin-1 in Neonatal Hypoxic-Ischemic Encephalopathy and Its Underlying Mechanism

Zhen Zhang 1ABCDEFG* , Xin Chen 1ABCDEFG* , Sichen Liu 2BCEFG*

DOI: 10.12659/MSM.924544

Med Sci Monit 2020; 26:e924544

Figure 1 SIRT1 expression was downregulated in the HIE rat brain tissues. (A) Cell apoptosis of rat brain tissues was analyzed using flow cytometry. (B) Cell apoptosis rate was calculated and presented (n=5). (C) The levels of the related molecular markers S100B and NSE during the development of HIE were measured by Western blot. (D) Western blot analysis of SIRT1 levels. (E) qRT-PCR analysis of SIRT1 mRNA levels (n=5). The results showed as the mean ± SD. ** P<0.01 vs. control group. SIRT1 – sirtuin-1; HIE – hypoxic-ischemic encephalopathy; NSE – neuron-specific enolase; S100B – S100 calcium binding protein B.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750