28 June 2020>: Lab/In Vitro Research
Meteorin-Like (METRNL) Attenuates Myocardial Ischemia/Reperfusion Injury-Induced Cardiomyocytes Apoptosis by Alleviating Endoplasmic Reticulum Stress via Activation of AMPK-PAK2 Signaling in H9C2 Cells
Ling Xu A , Yinlian Cai CD , Yaoguo Wang B , Chaoxiang Xu C**DOI: 10.12659/MSM.924564
Med Sci Monit 2020; 26:e924564
Figure 6 PAK2 silencing reversed the inhibitive effect of METRNL overexpression on c ER stress induced by OGD/R. The expressions of GRP78, ATF4, ATF6, and CHOP were determined by western blot. Error bars represent the mean±SEM from 3 independent experiments. *** P<0.001 versus Control; ## P<0.01, ### P<0.001 versus OGD/R 12 hours; @ P<0.05, @@@ P<0.001 versus OGD/R+Ov-METRNL. PAK2 – p21-activated kinase 2; METRNL – Meteorin-like; ER – endoplasmic reticulum; OGD/R – oxygen-glucose deprivation and reperfusion; GRP78 – glucose-regulated protein 78; ATF – activating transcription factor; CHOP – C/EBP-homologus protein; SEM – standard error of the mean.