Figure 1 Construction and mechanism of 3BP-LCNP-FA. Synthetic process and structure of 3BP-LCNP-FA. 3-bromopyruvate is a hydrophilic drug and located in the hydrophilic segment of the phospholipid bilayer. 3BP-LCNP-FA is injected into the blood stream by intraperitoneal injection, and the drug is transported into tumor cells based on the enhanced permeability and retention effect and folate receptor-mediated endocytosis. After local release of the drug, hexokinase on the mitochondria can inhibit the ATP acquisition of tumor cells and cause cell death without affecting normal cells. (The following images represent three independent experiments).