A Composite Tissue Engineered Bone Material Consisting of Bone Mesenchymal Stem Cells, Bone Morphogenetic Protein 9 (BMP9) Gene Lentiviral Vector, and P3HB4HB Thermogel (BMSCs-LV-BMP9-P3HB4HB) Repairs Calvarial Skull Defects in Rats by Expression of Osteogenic Factors

Cheng Zhou; Chuan Ye; Chen Zhao; Junyi Liao; Yuwan Li; Hong Chen; Wei Huang

doi:10.12659/MSM.924666

07 September 2020: Animal Study

A Composite Tissue Engineered Bone Material Consisting of Bone Mesenchymal Stem Cells, Bone Morphogenetic Protein 9 (BMP9) Gene Lentiviral Vector, and P3HB4HB Thermogel (BMSCs-LV-BMP9-P3HB4HB) Repairs Calvarial Skull Defects in Rats by Expression of Osteogenic Factors

Cheng Zhou ^1BCDEF , Chuan Ye ^2BCDF , Chen Zhao ^1BCD , Junyi Liao ^1BCF , Yuwan Li ^1BC , Hong Chen ^1BF , Wei Huang ^1ADEG*

DOI: 10.12659/MSM.924666

Med Sci Monit 2020; 26:e924666

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Figure 1 BMSCs derived from rats demonstrated obvious adipogenic potential and osteogenic potential. (A) Adipogenic differentiation of BMSCs determined by ORO staining. (B) Osteogenic differentiation of BMSCs determined by Alizarin red staining. (C) Osteogenic differentiation of BMSCs by ALP staining. ORO – oil-red O staining; BMSCs – bone mesenchymal stem cells; ALP – alkaline phosphatase.

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A Composite Tissue Engineered Bone Material Consisting of Bone Mesenchymal Stem Cells, Bone Morphogenetic Protein 9 (BMP9) Gene Lentiviral Vector, and P3HB4HB Thermogel (BMSCs-LV-BMP9-P3HB4HB) Repairs Calvarial Skull Defects in Rats by Expression of Osteogenic Factors

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