A Composite Tissue Engineered Bone Material Consisting of Bone Mesenchymal Stem Cells, Bone Morphogenetic Protein 9 (BMP9) Gene Lentiviral Vector, and P3HB4HB Thermogel (BMSCs-LV-BMP9-P3HB4HB) Repairs Calvarial Skull Defects in Rats by Expression of Osteogenic Factors

Cheng Zhou; Chuan Ye; Chen Zhao; Junyi Liao; Yuwan Li; Hong Chen; Wei Huang

doi:10.12659/MSM.924666

07 September 2020 : Animal Research

A Composite Tissue Engineered Bone Material Consisting of Bone Mesenchymal Stem Cells, Bone Morphogenetic Protein 9 (BMP9) Gene Lentiviral Vector, and P3HB4HB Thermogel (BMSCs-LV-BMP9-P3HB4HB) Repairs Calvarial Skull Defects in Rats by Expression of Osteogenic Factors

Cheng Zhou^1BCDEF, Chuan Ye^2BCDF, Chen Zhao^1BCD, Junyi Liao^1BCF, Yuwan Li^1BC, Hong Chen^1BF, Wei Huang^1ADEG*

DOI: 10.12659/MSM.924666

Med Sci Monit 2020; 26:e924666

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Figure 10 BMSC+LV-BMP9+P3HB4HB composite bone repair material promoted expression of osteogenic factors in novel regenerated tissues of calvarial defect rats, according to immunohistochemistry assay (IHC). (A) RUNX2 expression in regenerated tissues. (B) OCN expression in regenerated tissues. (C) OPN expression in regenerated tissues. BMSCs – bone mesenchymal stem cells; OCN – osteocalcin; OPN – osteopontin.

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A Composite Tissue Engineered Bone Material Consisting of Bone Mesenchymal Stem Cells, Bone Morphogenetic Protein 9 (BMP9) Gene Lentiviral Vector, and P3HB4HB Thermogel (BMSCs-LV-BMP9-P3HB4HB) Repairs Calvarial Skull Defects in Rats by Expression of Osteogenic Factors

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