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07 September 2020: Animal Study

A Composite Tissue Engineered Bone Material Consisting of Bone Mesenchymal Stem Cells, Bone Morphogenetic Protein 9 (BMP9) Gene Lentiviral Vector, and P3HB4HB Thermogel (BMSCs-LV-BMP9-P3HB4HB) Repairs Calvarial Skull Defects in Rats by Expression of Osteogenic Factors

Cheng Zhou 1BCDEF , Chuan Ye 2BCDF , Chen Zhao 1BCD , Junyi Liao 1BCF , Yuwan Li 1BC , Hong Chen 1BF , Wei Huang 1ADEG*

DOI: 10.12659/MSM.924666

Med Sci Monit 2020; 26:e924666

Figure 10 BMSC+LV-BMP9+P3HB4HB composite bone repair material promoted expression of osteogenic factors in novel regenerated tissues of calvarial defect rats, according to immunohistochemistry assay (IHC). (A) RUNX2 expression in regenerated tissues. (B) OCN expression in regenerated tissues. (C) OPN expression in regenerated tissues. BMSCs – bone mesenchymal stem cells; OCN – osteocalcin; OPN – osteopontin.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750