A Composite Tissue Engineered Bone Material Consisting of Bone Mesenchymal Stem Cells, Bone Morphogenetic Protein 9 (BMP9) Gene Lentiviral Vector, and P3HB4HB Thermogel (BMSCs-LV-BMP9-P3HB4HB) Repairs Calvarial Skull Defects in Rats by Expression of Osteogenic Factors

Cheng Zhou; Chuan Ye; Chen Zhao; Junyi Liao; Yuwan Li; Hong Chen; Wei Huang

doi:10.12659/MSM.924666

07 September 2020 : Animal Research

A Composite Tissue Engineered Bone Material Consisting of Bone Mesenchymal Stem Cells, Bone Morphogenetic Protein 9 (BMP9) Gene Lentiviral Vector, and P3HB4HB Thermogel (BMSCs-LV-BMP9-P3HB4HB) Repairs Calvarial Skull Defects in Rats by Expression of Osteogenic Factors

Cheng Zhou^1BCDEF, Chuan Ye^2BCDF, Chen Zhao^1BCD, Junyi Liao^1BCF, Yuwan Li^1BC, Hong Chen^1BF, Wei Huang^1ADEG*

DOI: 10.12659/MSM.924666

Med Sci Monit 2020; 26:e924666

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Figure 6 BMSCs-LV-BMP9-P3HB4HB significantly triggered osteogenic differentiation of BMSCs at 1 day, 3 days, and 7 days after co-culture, according to both Alizarin red staining and ALP staining. (A) Alizarin red staining for osteogenic differentiation of BMSCs. (B) ALP staining for osteogenic differentiation of BMSCs. BMSCs – bone mesenchymal stem cells; BMP9 – bone morphogenetic protein; ALP – alkaline phosphatase.

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A Composite Tissue Engineered Bone Material Consisting of Bone Mesenchymal Stem Cells, Bone Morphogenetic Protein 9 (BMP9) Gene Lentiviral Vector, and P3HB4HB Thermogel (BMSCs-LV-BMP9-P3HB4HB) Repairs Calvarial Skull Defects in Rats by Expression of Osteogenic Factors

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