Retinoic Acid-Platinum (II) Complex [RT-Pt(II)] Protects Against Rheumatoid Arthritis in Mice via MEK/Nuclear Factor kappa B (NF-κB) Pathway Downregulation

Ziqiang Cui; Yaping Lin; Yuhong Liu; Ling Cao; Li Cui

doi:10.12659/MSM.924787

03 August 2020: Animal Study

Retinoic Acid-Platinum (II) Complex [RT-Pt(II)] Protects Against Rheumatoid Arthritis in Mice via MEK/Nuclear Factor kappa B (NF-κB) Pathway Downregulation

Ziqiang Cui ^1BCDE , Yaping Lin ^2BCD , Yuhong Liu ^3BCEF , Ling Cao ^3BDE , Li Cui ^3ACDEF*

DOI: 10.12659/MSM.924787

Med Sci Monit 2020; 26:e924787

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Figure 2 Effect of RT-Pt(II) on MH7A cell apoptosis. The RT-Pt(II) exposed cells at 4 and 12 μM concentrations were treated with TNF-α at 48 h. (A) The cellular apoptosis at 72 h of RT-Pt(II) treatment was analyzed by flow cytometry. (B) The protein expression at 72 h of RT-Pt(II) treatment was assessed by western blotting.

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Retinoic Acid-Platinum (II) Complex [RT-Pt(II)] Protects Against Rheumatoid Arthritis in Mice via MEK/Nuclear Factor kappa B (NF-κB) Pathway Downregulation

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