03 August 2020>: Animal Study
Retinoic Acid-Platinum (II) Complex [RT-Pt(II)] Protects Against Rheumatoid Arthritis in Mice via MEK/Nuclear Factor kappa B (NF-κB) Pathway Downregulation
Ziqiang Cui 1BCDE , Yaping Lin 2BCD , Yuhong Liu 3BCEF , Ling Cao 3BDE , Li Cui 3ACDEF*DOI: 10.12659/MSM.924787
Med Sci Monit 2020; 26:e924787
Figure 3 (A–E) Effect RT-Pt(II) on matrix metalloproteinase-1/-13 and interleukins-1β/-6/-8 levels. The RT-Pt(II) exposed cells at 4 and 12 μM concentrations for 48 h were treated with TNF-α. The level of proteins was detected using ELISA assays at 72 h of RT-Pt(II) treatment. * P<0.02 and ** P<0.01 vs. TNF-α treated control