Retinoic Acid-Platinum (II) Complex [RT-Pt(II)] Protects Against Rheumatoid Arthritis in Mice via MEK/Nuclear Factor kappa B (NF-κB) Pathway Downregulation

Ziqiang Cui; Yaping Lin; Yuhong Liu; Ling Cao; Li Cui

doi:10.12659/MSM.924787

03 August 2020 : Animal Research

Retinoic Acid-Platinum (II) Complex [RT-Pt(II)] Protects Against Rheumatoid Arthritis in Mice via MEK/Nuclear Factor kappa B (NF-κB) Pathway Downregulation

Ziqiang Cui^1BCDE, Yaping Lin^2BCD, Yuhong Liu^3BCEF, Ling Cao^3BDE, Li Cui^3ACDEF*

DOI: 10.12659/MSM.924787

Med Sci Monit 2020; 26:e924787

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Figure 3 (A–E) Effect RT-Pt(II) on matrix metalloproteinase-1/-13 and interleukins-1β/-6/-8 levels. The RT-Pt(II) exposed cells at 4 and 12 μM concentrations for 48 h were treated with TNF-α. The level of proteins was detected using ELISA assays at 72 h of RT-Pt(II) treatment. * P<0.02 and ** P<0.01 vs. TNF-α treated control

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Retinoic Acid-Platinum (II) Complex [RT-Pt(II)] Protects Against Rheumatoid Arthritis in Mice via MEK/Nuclear Factor kappa B (NF-κB) Pathway Downregulation

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