03 August 2020: Animal Study
Retinoic Acid-Platinum (II) Complex [RT-Pt(II)] Protects Against Rheumatoid Arthritis in Mice via MEK/Nuclear Factor kappa B (NF-κB) Pathway Downregulation
Ziqiang Cui 1BCDE , Yaping Lin 2BCD , Yuhong Liu 3BCEF , Ling Cao 3BDE , Li Cui 3ACDEF*DOI: 10.12659/MSM.924787
Med Sci Monit 2020; 26:e924787
Figure 7 Effect of RT-Pt(II) on NF-κB p65 level, interleukins-1β/-6 and MMP-1/-13 activities. The RA rats untreated or treated with RT-Pt(II) at 2 mg/kg and 5 mg/kg doses were assessed for (A) NF-κB p65 level and activities of (B) IL-1β and (C) IL-6 on day 21 of the treatment. * P<0.02 and ** P<0.01 vs. untreated RA rats.