29 September 2020>: Clinical Research
HMGA1 Promotes Hepatic Metastasis of Colorectal Cancer by Inducing Expression of Glucose Transporter 3 (GLUT3)Meijing Yang 1ABC* , Yang Guo 1DE* , Xiaoyun Liu 2E , Naiqing Liu 3ABCDEF*
Med Sci Monit 2020; 26:e924975
Figure 3 HMGA1 induced the expression and transcription of GLUT3 in CRCLM. (A) Representative IHC images of GLUT3 high and low expression. (B) Patients with high HMGA1 expression had higher IHC scores of GLUT3. The t test showed a statistically significant difference. (C) In the qPCR of 17 synchronous CRCLMs, GLUT3 expression changed along with the HMGA1 mRNA. Spearman correlation analysis showed a statistically significant difference. (D) HMGA1 knockdown substantially decreased the expression of GLUT3. In SW480 cells, HMGA1 was silenced by 2 independent siRNAs. (E) HMGA1 knockdown decreased the transcription of GLUT3. The transcription of GLUT3 was detected with luciferase in SW480 cells after silencing HMGA1.