Positive Cross-Talk Between CXC Chemokine Receptor 4 (CXCR4) and Epidermal Growth Factor Receptor (EGFR) Promotes Gastric Cancer Metastasis via the Nuclear Factor kappa B
(NF-kB)-Dependent Pathway

Yu Cheng; Xiaofang Che; Simeng Zhang; Tianshu Guo; Xin He; Yunpeng Liu; Xiujuan Qu

doi:10.12659/MSM.925019

03 September 2020 : Clinical Research

Positive Cross-Talk Between CXC Chemokine Receptor 4 (CXCR4) and Epidermal Growth Factor Receptor (EGFR) Promotes Gastric Cancer Metastasis via the Nuclear Factor kappa B (NF-kB)-Dependent Pathway

Yu Cheng^123ABCDEG, Xiaofang Che^123A, Simeng Zhang^123C, Tianshu Guo^123F, Xin He^123F, Yunpeng Liu^123AG*, Xiujuan Qu^123AG

DOI: 10.12659/MSM.925019

Med Sci Monit 2020; 26:e925019

Authors information Article notes Copyright and License information

Related articles Order reprints Share article Share by email

View HTML version

Figure 6 A working model for amplified cross-talk between CXCR4 and EGFR to promote gastric cancer metastasis. A positive feedback loop of CXCR4/EGFR-NF-κB-CXCR4/EGFR exists in the gastric cancer signaling network, which ultimately increases gastric cancer cellular metastasis.

Back to the Article

Positive Cross-Talk Between CXC Chemokine Receptor 4 (CXCR4) and Epidermal Growth Factor Receptor (EGFR) Promotes Gastric Cancer Metastasis via the Nuclear Factor kappa B (NF-kB)-Dependent Pathway

Your Privacy