23 August 2020>: Database Analysis
Integrated Bioinformatics Analysis Reveals Potential Pathway Biomarkers and Their Interactions for Clubfoot
Jing Ding BCDEF* , Zhenpeng Liang BCDE* , Weijia Feng EF , Qixun Cai AG* , Ziming Zhang AG*DOI: 10.12659/MSM.925249
Med Sci Monit 2020; 26:e925249
Figure 6 Protein-protein Interactions (PPI) and Gene Regulatory Networks (GRN) of the candidate genes by NetworkAnalyst. (A) Generic PPI. (B) Gene-miRNA Interactome. (C) Transcription factor (TF)-gene interaction database. (D) TF-miRNA coregulatory interaction. Right was the top 10 genes in the 4 aforementioned interactions in A–D. (E) Top 10 interactions. The order from left to right is PPI, Gene-miRNA, TF-gene interaction, and TF-miRNA coregulatory interaction. (F) The distribution and frequency of the top 10 genes in the 4 aforementioned interactions. Left: distribution. Right: frequency. (G) Proposed theories of clubfoot.