21 September 2020: Lab/In Vitro Research
P2X7 Receptor (P2X7R) of Microglia Mediates Neuroinflammation by Regulating (NOD)-Like Receptor Protein 3 (NLRP3) Inflammasome-Dependent Inflammation After Spinal Cord Injury
Xiao Fan 12ABCEF* , Wei Ma 3ABCEF* , Yingyu Zhang 1BCD , Li Zhang 24AFG*DOI: 10.12659/MSM.925491
Med Sci Monit 2020; 26:e925491
Figure 4 P2X7R of microglia in spinal cord regulated the expression of NLRP3 and cleaved-Caspase-1 (P20). Compared to the sham group, the expression of NLRP3 and cleaved-Caspase-1 (P20) in the spinal cord significantly increased after spinal cord injury (** P<0.01) and, compared to the model group, BzATP promoted the expression of NLRP3 and cleaved-Caspase-1 (P20) (* P<0.05), which was inhibited by CY-09 (* P<0.05), while A-438079 notably reduced the expression of NLRP3 and cleaved-Caspase-1 (P20) (** P<0.01).