30 September 2020>: Animal Study
Efficacy, Drug Sensitivity, and Safety of a Chronic Ocular Hypertension Rat Model Established Using a Single Intracameral Injection of Hydrogel into the Anterior Chamber
Huan Yu 1BCE* , Huimin Zhong 2CDF* , Junjue Chen 1DF , Jun Sun 1BF , Ping Huang 3EF , Xing Xu 3CE , Shouyue Huang 1ADE , Yisheng Zhong 1AG*DOI: 10.12659/MSM.925852
Med Sci Monit 2020; 26:e925852
Figure 3 Intraocular pressure (IOP) changes of the rats administered continuously for 1 week. IOP of rats treated with brimonidine, timolol, and bimatoprost were significantly lower than in the control group at 2–7 days after administration, and the difference was statistically significant (P<0.05). The IOP of the rats treated with brinzolamide and pilocarpine were not significantly different from the control group at 2–7 days after administration (P>0.05).