Figure 5 Drynaria total flavonoids (DTF) improved the histopathological changes in rat mandibles after ovary removal. The histopathological changes of the mandible of each group were investigated by H&E staining (×100). (A) Sham group, (B) ovariectomy control (OVX) group, (C) low-dose group, (D) middle-dose group, and (E) high-dose group. The arrows indicate the osteoporotic lesions in the mandible, including abnormal bone resorption, reduced number of trabeculae, and bite-like changes.