18 November 2020 : Animal Research
Reduced Amygdala Microglial Expression of Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B (TrkB) in a Rat Model of Poststroke Depression
Han-xiao Zhu1ACE, Li-jing Cheng1ABCE, Ri-wei Ou Yang1CD, Yang-yang Li1CDF, Jian Liu1BCD, Dan Dai1DF, Wei Wang1BF, Ning Yang1BDF, Yun Li2AG*DOI: 10.12659/MSM.926323
Med Sci Monit 2020; 26:e926323
Figure 5 Dual-immunofluorescence detection of BDNF or TrkB expression by amygdala neuron 4 weeks after CUMS. (A) BDNF or TrkB expression (red fluorescence) in NeuN-positive neuron (green fluorescence, merged yellow fluorescence) (bar=20 μm). (B) Histograms show the number of BDNF/NeuN- or TrkB/NeuN-positive cells in amygdala of each group. N=5 rats/group. * P<0.05 versus normal control rats; @ P<0.05 versus depression model rats;# P<0.05 versus stroke model rats. BDNF – brain-derived neurotrophic factor; CUMS – chronic unpredictable mild stress; TrkB – tyrosine kinase receptor B.