18 November 2020 : Animal Research
Reduced Amygdala Microglial Expression of Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B (TrkB) in a Rat Model of Poststroke Depression
Han-xiao Zhu1ACE, Li-jing Cheng1ABCE, Ri-wei Ou Yang1CD, Yang-yang Li1CDF, Jian Liu1BCD, Dan Dai1DF, Wei Wang1BF, Ning Yang1BDF, Yun Li2AG*DOI: 10.12659/MSM.926323
Med Sci Monit 2020; 26:e926323
Figure 7 Effects of t-PA, proBDNF, and NS ICV injection on microglial expression of BDNF or TrkB in the amygdala 1 week after injection. (A) BDNF or TrkB expression (red fluorescence) in CD11b-positive microglia (green fluorescence) (bar=20 μm). (B) Histograms show the number of BDNF/CD11b- or TrkB/CD11b-positive cells in microglia of PSD model rats 1 week after ICV injection. N=5 rats/group. * P<0.05 versus NS injection; # p<0.05 versus tPA injection. BDNF – brain-derived neurotrophic factor; ICV – intracerebroventricular; NS – normal saline; PSD – poststroke depression; t-PA – tissue plasminogen activator; TrkB – tyrosine kinase receptor B.