18 November 2020: Animal Study
Reduced Amygdala Microglial Expression of Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B (TrkB) in a Rat Model of Poststroke Depression
Han-xiao Zhu 1ACE* , Li-jing Cheng 1ABCE* , Ri-wei Ou Yang 1CD , Yang-yang Li 1CDF , Jian Liu 1BCD , Dan Dai 1DF , Wei Wang 1BF , Ning Yang 1BDF , Yun Li 2AG*DOI: 10.12659/MSM.926323
Med Sci Monit 2020; 26:e926323
Figure 7 Effects of t-PA, proBDNF, and NS ICV injection on microglial expression of BDNF or TrkB in the amygdala 1 week after injection. (A) BDNF or TrkB expression (red fluorescence) in CD11b-positive microglia (green fluorescence) (bar=20 μm). (B) Histograms show the number of BDNF/CD11b- or TrkB/CD11b-positive cells in microglia of PSD model rats 1 week after ICV injection. N=5 rats/group. * P<0.05 versus NS injection; # p<0.05 versus tPA injection. BDNF – brain-derived neurotrophic factor; ICV – intracerebroventricular; NS – normal saline; PSD – poststroke depression; t-PA – tissue plasminogen activator; TrkB – tyrosine kinase receptor B.