12 October 2020>: Animal Study
Chrysophanol Protects Against Acute Heart Failure by Inhibiting JNK1/2 Pathway in Rats
Xiao-Jiang Xie 1BCDE , Chang-Qing Li 1ACF*DOI: 10.12659/MSM.926392
Med Sci Monit 2020; 26:e926392
Figure 1 Chrysophanol improved the heart functions in AHF rats. AHF rat models were constructed using Sprague-Dawley rats that then received different treatments. Echocardiography of the heart was performed to evaluate the heart functions. (A) Left ventricular peak systolic pressure; (B) Left ventricular end-diastolic pressure; (C) Maximum rate of rise of left ventricular pressure; (D) Maximum rate of fall of left ventricular pressure. Each experiment was repeated 3 times. Data are expressed as mean±SEM. * p<0.05, ** p<0.01 vs. sham; # p<0.05, ## p<0.01 vs. AHF; $ p<0.05, $$ p<0.01 vs. AHF+CHR. AHF – acute heart failure; CHR – chrysophanol; SP – SP600125; Be – benazepril.