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12 October 2020: Animal Study

Chrysophanol Protects Against Acute Heart Failure by Inhibiting JNK1/2 Pathway in Rats

Xiao-Jiang Xie 1BCDE , Chang-Qing Li 1ACF*

DOI: 10.12659/MSM.926392

Med Sci Monit 2020; 26:e926392

Figure 6 (A, B) Chrysophanol inhibited the activation of JNK1/2 pathway. After various treatments, rats were sacrificed and myocardial tissues were collected to isolate proteins. The expression levels of protein related the MAPK pathway were determined by western blot. Each experiment was repeated 3 times. Data are expressed as mean±SEM. * p<0.05, ** p<0.01 vs. sham; # p<0.05, ## p<0.01 vs. AHF; $ p<0.05, $$ p<0.01 vs. AHF+CHR. AHF – acute heart failure; CHR – chrysophanol; SP – SP600125; Be – benazepril.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750