28 September 2020 : Animal Research
Ability of Post-treatment Glycyrrhizic Acid to Mitigate Cerebral Ischemia/Reperfusion Injury in Diabetic Mice
Yuan Li12BCD, Na Yao3ACF, Ting Zhang3D, Fengying Guo4B, Xiangying Niu5F, Zhihui Wu3E, Shaozhang Hou3AEFG*DOI: 10.12659/MSM.926551
Med Sci Monit 2020; 26:e926551
Figure 2 GA suppressed expression of Myd88 and other factors involved in inflammatory reactions. (A) TLR4 and HMGB1 protein expression, as shown by western blotting. (B, C) Quantitation of the results in A. (D). Immunofluorescence staining of NF-κB; the merged area indicates active transcription. (E) Percentages of NF-κB positive cells. (F–H) Serum concentrations of TNF-α, IL-6 and IL-1β. Each point is representative of 6 mice. The 2 ends of each horizontal line are the 2 groups being compared, * p<0.05, ** p<0.001, *** p<0.0001.