09 January 2021 : Animal Research
Therapeutic Effect of an Anti-Human Programmed Death-Ligand 1 (PD-L1) Nanobody on Polymicrobial Sepsis in Humanized Mice
Zhen-zhen Zhao1ABCDG, Xiao-lin Wang1ABCD, Jian Xie1ABCDF, Li-ping Chen2B, Qian Li2B, Xiao-xiao Wang3B, Jia-feng Wang1ACDEFG*, Xiao-ming Deng1ACDEFGDOI: 10.12659/MSM.926820
Med Sci Monit 2021; 27:e926820
Figure 1 Anti-programmed death-ligand 1 (PD-L1) expression is upregulated in peripheral lymphocytes, monocytes, and neutrophils from septic mice with PD-L1 humanization at 24 h after cecal ligation and puncture (CLP) surgery. Data shown as mean±standard deviation (SD) (n=6 per group). P<0.05 vs. sham group. CLP – cecal ligation and puncture.