09 January 2021 : Animal Research
Therapeutic Effect of an Anti-Human Programmed Death-Ligand 1 (PD-L1) Nanobody on Polymicrobial Sepsis in Humanized Mice
Zhen-zhen Zhao1ABCDG, Xiao-lin Wang1ABCD, Jian Xie1ABCDF, Li-ping Chen2B, Qian Li2B, Xiao-xiao Wang3B, Jia-feng Wang1ACDEFG*, Xiao-ming Deng1ACDEFGDOI: 10.12659/MSM.926820
Med Sci Monit 2021; 27:e926820
Figure 4 (A, B) KN035 alleviated the sepsis-induced organ injury in the lungs and livers of cecal ligation and puncture (CLP) mice. Data shown as median, minimum, and maximum values (n=6 per group). * P<0.05 vs. CLP group and isotype group, # P<0.05 vs. sham group. CLP – cecal ligation and puncture.