09 January 2021>: Animal Study
Therapeutic Effect of an Anti-Human Programmed Death-Ligand 1 (PD-L1) Nanobody on Polymicrobial Sepsis in Humanized Mice
Zhen-zhen Zhao 1ABCDG* , Xiao-lin Wang 1ABCD* , Jian Xie 1ABCDF* , Li-ping Chen 2B , Qian Li 2B , Xiao-xiao Wang 2B , Jia-feng Wang 1ACDEFG* , Xiao-ming Deng 1ACDEFG*DOI: 10.12659/MSM.926820
Med Sci Monit 2021; 27:e926820
Figure 5 (A–C) KN035 reversed sepsis-induced apoptosis in the spleen (×400) and enhanced the bacterial clearance capacity. Data shown as mean±standard deviation (n=6 per group). * P<0.05 vs. Cecal ligation and puncture group and isotype group, # P<0.05 vs. sham group. CLP – cecal ligation and puncture; PLF – peritoneal lavage fluid.