17 August 2020>: Animal Study
Omipalisib Inhibits Esophageal Squamous Cell Carcinoma Growth Through Inactivation of Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) and ERK SignalingDong-shan Zhu 1ABCDEF , Jing-yao Dong 1BCF , Yao-yao Xu 2BCD , Xin-tong Zhang 2BCD , Shi-bo Fu 2ACEFG* , Wei Liu 1ACEFG*
Med Sci Monit 2020; 26:e927106
Figure 1 Omipalisib was identified as a potential agent against Esophageal squamous cell carcinoma (ESCC). (A) MTT assay was used to screen compounds in a 1404-compound library. (B) In total, 13 compounds showed inhibitory effects on 4 ESCC cell lines. (C) Chemical structure of omipalisib.