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17 August 2020: Animal Study

Omipalisib Inhibits Esophageal Squamous Cell Carcinoma Growth Through Inactivation of Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) and ERK Signaling

Dong-shan Zhu 1ABCDEF , Jing-yao Dong 1BCF , Yao-yao Xu 2BCD , Xin-tong Zhang 2BCD , Shi-bo Fu 2ACEFG* , Wei Liu 1ACEFG*

DOI: 10.12659/MSM.927106

Med Sci Monit 2020; 26:e927106

Figure 4 Omipalisib induced cell cycle arrest of Esophageal squamous cell carcinoma (ESCC) cells. (A) Representative data of 3 independent experiments in cell cycle distribution determined by flow cytometry in ESCC cells exposed to omipalisib for 24 hours. (B) Representative image of protein expression of 3 independent experiments in 4 ESCC cells exposed to omipalisib for 24 hours. (C) Density analysis of protein bands performed with ImageJ software. Plot is the average of 3 independent experiments. (* P<0.05, ** P<0.01, *** P<0.001).

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750