17 August 2020: Animal Study
Omipalisib Inhibits Esophageal Squamous Cell Carcinoma Growth Through Inactivation of Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) and ERK Signaling
Dong-shan Zhu 1ABCDEF , Jing-yao Dong 1BCF , Yao-yao Xu 2BCD , Xin-tong Zhang 2BCD , Shi-bo Fu 2ACEFG* , Wei Liu 1ACEFG*DOI: 10.12659/MSM.927106
Med Sci Monit 2020; 26:e927106
Figure 6 Identification of potential signaling pathways of omipalisib with RNA-seq assays. (A, B) DEGs indicated that the mTOR signaling pathway is the major pathway affected by omipalisib treatment according to KEGG pathway enrichment analysis (A) and GSEA (B). (C) qRT-PCR assays showed obvious alterations in DDIT4 and CCND1 gene expression, and the tendency was consistent with the RNA-seq results. (*** P<0.001).