17 August 2020>: Animal Study
Omipalisib Inhibits Esophageal Squamous Cell Carcinoma Growth Through Inactivation of Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) and ERK SignalingDong-shan Zhu 1ABCDEF , Jing-yao Dong 1BCF , Yao-yao Xu 2BCD , Xin-tong Zhang 2BCD , Shi-bo Fu 2ACEFG* , Wei Liu 1ACEFG*
Med Sci Monit 2020; 26:e927106
Figure 8 Omipalisib inhibited the growth of Esophageal squamous cell carcinoma (ESCC) in vivo. (A) Representative image of mice administered different doses of omipalisib at the end of the experiment. (B) Tumor volume was calculated by the following equation: volume=long diameter×(short diameter)2/2. (C) Body weight was recorded every 2 days during the course of omipalisib administration. (D) Protein expression in tumor tissue from KYSE150-bearing mice by Western blot. (E) Density analysis of protein bands were performed with ImageJ software. (* P<0.05, ** P<0.01, *** P<0.001).