05 November 2020 : Laboratory Research
Integrated Bioinformatics Analysis of Hub Genes and Pathways Associated with a Compression Model of Spinal Cord Injury in Rats
Chang Jiang1BCE, Zheng Li1BCE, Zhaoyi Wu1DEF, Yun Liang1CD, Lixia Jin1BD, Yuanwu Cao1CG, Shengcheng Wan1DG, Zixian Chen1AG*DOI: 10.12659/MSM.927107
Med Sci Monit 2020; 26:e927107
Figure 4 (A–D) Hub genes were identified in 4 sets through weighted gene coexpression network analysis (WGCNA). It was found that set A had 3 subparts, Cyp2d1 was the hub gene of set A, which was the core of the network, and C2 and Cyth4 were the key nodes that linked the other 2 parts. The other 3 sets exhibited their respective aggregations. Bub1b and Tpx2 were hub genes of set B. Similarly, Atp1a3 was the hub gene of set C, while Rrp9 and Pgam5 were hub genes of set D. Line thickness represented connection weight. The size and color of the nodes represented the degree of connectivity.