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23 October 2020: Animal Study

Long Non-Coding RNA Nuclear-Enriched Abundant Transcript 1 (NEAT1) Represses Proliferation of Trophoblast Cells in Rats with Preeclampsia via the MicroRNA-373/FLT1 Axis

Lingling Teng 1ABEF* , Pingping Liu 2ABDE* , Xiao Song 3BCE , Hui Wang 4CEF , Jing Sun 5BDE , Zhongxia Yin 6CDEF*

DOI: 10.12659/MSM.927305

Med Sci Monit 2020; 26:e927305

Figure 3 miR-373 enhances trophoblast cell migration and invasion. (A) RT-qPCR measurements of miR-373 expression in placentas of PE and control rats (** p<0.01 by unpaired t test); (B) EdU positivity in trophoblast cells transfected with miR-373 mimic/inhibitor or controls (* p<0.05 by 1-way ANOVA); (C) invasion and migration ability of cells, as measured by Transwell assays (* p<0.05 by 1-way ANOVA); (D) cell apoptosis measured by flow cytometry (* p<0.05 by 1-way ANOVA). Each figure represents the average of 3 replicates.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750