28 October 2020: Lab/In Vitro Research
Upregulation of Serine Proteinase Inhibitor Clade B Member 3 (SERPINB3) Expression by Stromal Cell-Derived Factor (SDF-1)/CXCR4/Nuclear Factor kappa B (NF-κB) Promotes Migration and Invasion of Gastric Cancer Cells
Jing Gong 1ABCDEF* , Yongxi Song 2AB* , Ling Xu 3ACEF , Xiaofang Che 3DEF , Kezuo Hou 3BC , Tianshu Guo 3BC , Yu Cheng 3ABG , Yunpeng Liu 3ADE* , Xiujuan Qu 3AG*DOI: 10.12659/MSM.927411
Med Sci Monit 2020; 26:e927411
Figure 6 Representative images for CXCR4 and SERPINB3 immunohistochemical staining in gastric cancer tissues along with overall survival. (A) H&E staining of GC tissue, with negative control and positive expression shown by immunohistochemistry (×200). CXCR4-positive staining was observed in the cell membrane and cytoplasm (in brown). SERPINB3-positive staining was observed in cell nuclei and cytoplasm (in brown). (B) Overall survival (OS) of SERPINB3-positive or SERPINB3-negative patients with gastric cancer was estimated by the Kaplan-Meier method and log-rank test (n=96, P<0.05). (C) OS of CXCR4-positive or CXCR4-negative patients with gastric cancer was estimated by the Kaplan-Meier method and log-rank test (n=96, P=0.036). (D) OS of CXCR4-positive and SERPINB3-positive patients with gastric cancer was estimated by the Kaplan-Meier method and log-rank test (n=96, P<0.05). (E) Among the CXCR4-positive patients, the OS of SERPINB3-positive patients was estimated by the Kaplan-Meier method and log-rank test (P<0.001). (F) Among the CXCR4-negative patients, the OS of SERPINB3-positive patients was estimated by the Kaplan-Meier method and log-rank test (P=0.102).
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