20 December 2020 : Animal Research
Effect of Asthma on Erectile Dysfunction in Rats as Determined by Biological Network Analysis
Jisheng Wang12ABCDEF, Xuefeng Gong3ABCDEF, Sheng Deng12ABCDEF, Fanchao Meng12CDE, Hengheng Dai12DEF, Binghao Bao12CD, Junlong Feng12BF, Haisong Li2AFG*, Bin Wang2AFGDOI: 10.12659/MSM.927491
Med Sci Monit 2020; 26:e927491
Figure 1 Study flow chart. On the basis of the DAVID database, we predicted the proteins and pathways associated with asthma and erectile dysfunction (ED). We used real-time quantitative polymerase chain reaction and western blotting to measure expression of insulin, albumin, vascular endothelial growth factor A, tumor necrosis factor, and interleukin 6 proteins and messenger ribonucleic acid in rat penis cells of each group. The results of in vivo experiments were consistent with the prediction results of bioinformatics analysis. Asthma can induce systemic inflammation and extensive vascular endothelial damage, which then leads to ED.