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15 June 2021: Animal Study

The Improvement Effect of Sodium Ferulate on the Formation of Pulmonary Fibrosis in Silicosis Mice Through the Neutrophil Alkaline Phosphatase 3 (NALP3)/Transforming Growth Factor-β1 (TGF-β1)/α-Smooth Muscle Actin (α-SMA) Pathway

Jingyin Han AE* , Yangmin Jia BCD , Shujuan Wang BCD , Xiaoyu Gan BCD

DOI: 10.12659/MSM.927978

Med Sci Monit 2021; 27:e927978

Figure 1 Sodium ferulate (SF) reduced the injury of silicosis mice, specifically lung lesions and fibrosis, by inhibiting vimentin, while having no effect on body weight. (A) The effect of SF on lung tissue lesions in the silicosis mice was observed by hematoxylin-eosin staining (magnification×100, n=10, scale bars=100 μm). (B) The effect of SF on body weight of silicosis mice (n=10). (C–E) The effect of SF on vimentin protein and mRNA expression in silicosis mice was detected by western blot and quantitative real-time polymerase chain reaction (qRT-PCR). Expression levels were normalized with GAPDH. (F) The effect of SF on pulmonary fibrosis in silicosis mice (magnification×100, n=10, scale bars=100 μm). All experiments were performed in triplicate, and data are expressed as mean±standard deviation (SD). *** P<0.001 vs control 8 weeks; ### P<0.001 vs model 4 weeks+physiological saline (PS) 4 weeks.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750