04 January 2021 : Animal Research
Effect of Parecoxib Sodium on Myocardial Ischemia-Reperfusion Injury Rats
Fangyong Wu1AEG*, Wei Wang2ABD, Yingying Duan1BCF, Jia Guo1CD, Guanhua Li2BF, Tao Ma2DFDOI: 10.12659/MSM.928205
Med Sci Monit 2021; 27:e928205
Figure 2 Effect of parecoxib sodium on the expressions of apoptosis-related proteins in myocardial tissues. (A, B) Changes in Bcl-2 and Bax expressions in myocardial tissues detected using immunohistochemistry (IHC). The Sham group and I/R+Pare group had higher IHC scores of Bcl-2 and lower IHC scores of Bax than in the I/R group (P<0.05) (* P<0.05 vs. I/R group). (C) Changes in Bcl-2 and Bax expressions in myocardial tissues detected using western blotting. The Sham group and I/R+Pare group had an obviously higher protein expression of Bcl-2 and a lower protein expression of Bax than in the I/R group (P<0.05). (* P<0.05 vs. I/R group, ** P<0.01 vs. I/R group).