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09 March 2021: Lab/In Vitro Research

Gasdermin D Influence Mouse Podocytes Against High-Glucose-Induced Inflammation and Apoptosis via the C-Jun N-Terminal Kinase (JNK) Pathway

Huifang Li 1ABCDE , Kunxiao Zhao 2ADF , Ying Li 1ADFG*

DOI: 10.12659/MSM.928411

Med Sci Monit 2021; 27:e928411

Figure 1 Activation of GSDMD in HG-cultured mouse podocytes at various time points. (A–C) Western blot showing GSDMD and GSDMD-N protein expression levels in NG and HG-cultured mouse podocytes. (D) The expression of GSDMD-N mRNA was determined by RT-qPCR. (E) The expression of GSDMD in mouse podocytes was detected by immunofluorescence. NG – normal-glucose; HG – high-glucose; Data represent the average of 3 measurements. Mean±SD of 3 experiments is shown. * P<0.05, ** P<0.01 vs NG.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750