05 March 2021: Database Analysis
Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in Adrenocortical Carcinoma by Transcriptomic Analysis
Zhengqing Yang BE , Hui Cheng CD , Yazhou Zhang F , Yan Zhou AG*DOI: 10.12659/MSM.928523
Med Sci Monit 2021; 27:e928523
Figure 5 Association between NDRG4/CKS2 expression and survival of ACC patients. (A) Kaplan-Meier survival curve of overall survival in the TCGA-ACC cohort according to NDRG4 and CKS2 expression. (B) Survival curve of overall survival in the GSE76021 cohort according to NDRG4 and CKS2 expression. (C) Survival curve of disease-free survival in the TCGA-ACC cohort according to NDRG4 and CKS2 expression. (D) Survival analysis according to NDRG4 and CKS2 expression in ACC patients treated by mitotane therapy. (E, F) Receiver operating characteristic analysis of the tumor stage, CKS2 expression, NDRG4 expression, and the combined risk score for predicting 3-year survival (E) and 5-year survival (F) in the TCGA-ACC cohort. ACC – adrenocortical carcinoma.