05 March 2021: Database Analysis
Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in Adrenocortical Carcinoma by Transcriptomic Analysis
Zhengqing Yang BE , Hui Cheng CD , Yazhou Zhang F , Yan Zhou AG*DOI: 10.12659/MSM.928523
Med Sci Monit 2021; 27:e928523
Figure 6 Association between NDRG4/CKS2 expression and homologous recombination/mismatch repair pathways. (A) GSEA analysis of enriched pathways in NDRG4 low-expression samples. (B) Heatmap of genes in the homologous recombination pathway and NDRG4 expression. (C) Association between NDRG4 and BRCA1/BRCA2/EXO1/MSH2 expression in the TCGA-ACC cohort. (D) GSEA analysis of enriched pathways in CKS2 high-expression samples. (E) Heatmap of genes in mismatch repair pathways and CKS2 expression. (F) Association between CKS2 and BRCA1/BRCA2/EXO1/MSH2 expression in the TCGA-ACC cohort. GSEA, gene set enrichment analysis.