24 February 2021 : Clinical Research
Expression of Cell Division Cycle Protein 45 in Tissue Microarrays and the CDC45 Gene by Bioinformatics Analysis in Human Hepatocellular Carcinoma and Patient Outcomes
Hui-Ping Lu1ABCDEFG, Xiu-Fang Du1BCDEF, Jian-Di Li1BCDEF, Su-Ning Huang2ADEF, Rong-Quan He3ABDEF, Hua-Yu Wu4ABDEF, Ming-Fen Li5BCDEF, Wei-Zi Wu6CDEF, Ji-Tian Chen6BCDE, Wei-Jia Mo1ABCDEFG, Gang Chen1ABCDEFG*DOI: 10.12659/MSM.928800
Med Sci Monit 2021; 27:e928800
Figure 1 The clinical significance of CDC45 mRNA expression levels in hepatocellular carcinoma (HCC) tissues based on RNA-Seq data. The mRNA expression level of CDC45 was clearly upregulated compared with the controls (A, B). (A) The CDC45 mRNA expression was clearly higher in HCC than in normal tissues. (B) The CDC45 mRNA expression was significantly increased in HCC compared with normal tissues. (C) The CDC45 mRNA expression levels progressively increased from stage I to stage III and decreased in stage IV. A high CDC45 mRNA expression level indicated a negative prognosis (D: for overall survival, HR=1.9, P=0.00039; E: for disease-free survival, HR=1.6, P=0.0037). HR=hazard ratio.