Expression of Cell Division Cycle Protein 45 in Tissue Microarrays and the CDC45 Gene by Bioinformatics Analysis in Human Hepatocellular Carcinoma and Patient Outcomes

Hui-Ping Lu; Xiu-Fang Du; Jian-Di Li; Su-Ning Huang; Rong-Quan He; Hua-Yu Wu; Ming-Fen Li; Wei-Zi Wu; Ji-Tian Chen; Wei-Jia Mo; Gang Chen

doi:10.12659/MSM.928800

24 February 2021 : Clinical Research

Expression of Cell Division Cycle Protein 45 in Tissue Microarrays and the CDC45 Gene by Bioinformatics Analysis in Human Hepatocellular Carcinoma and Patient Outcomes

Hui-Ping Lu^1ABCDEFG, Xiu-Fang Du^1BCDEF, Jian-Di Li^1BCDEF, Su-Ning Huang^2ADEF, Rong-Quan He^3ABDEF, Hua-Yu Wu^4ABDEF, Ming-Fen Li^5BCDEF, Wei-Zi Wu^6CDEF, Ji-Tian Chen^6BCDE, Wei-Jia Mo^1ABCDEFG, Gang Chen^1ABCDEFG*

DOI: 10.12659/MSM.928800

Med Sci Monit 2021; 27:e928800

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Figure 2 The CDC45 mRNA expression levels were obviously upregulated in the microarrays from the Oncomine datasets. (A) Chen Liver: fold change=2.135; P=1.16E-10; 197 samples; 10 802 measured genes; platform not predefined in Oncomine. (B) Wurmbach Liver: fold change=1.581; P=4.17E-5; 75 samples; 19 574 measured genes; Human Genome U133 Plus 2.0 Array. (C) Roessler Liver: fold change=1.429; P=2.70E-5; 43 samples; 12 603 measured genes; Human Genome U133A 2.0 Array. (D) Roessler Liver 2: fold change=1.453; P=2.00E-36; 445 samples; 12 624 measured genes; Affymetrix Human Genome HT U133A Array.

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Expression of Cell Division Cycle Protein 45 in Tissue Microarrays and the CDC45 Gene by Bioinformatics Analysis in Human Hepatocellular Carcinoma and Patient Outcomes

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