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14 December 2020 : Review article  

Cell Sources and Influencing Factors of Liver Regeneration: A Review

Chengzhan Zhu12AEG, Bingzi Dong2FG, Leqi Sun3EF, Yixiu Wang1BCE, Shuhai Chen4AEF*

DOI: 10.12659/MSM.929129

Med Sci Monit 2020; 26:e929129

Figure 1 The schematic overview of hepatocyte-mediated liver regeneration (LR). In hepatic lobules, several types of mature hepatocytes have the characteristics of high replication capacity and plasticity. Axin2+ hepatocytes located around the central vein had stem cell-like characteristics; Mfsd2a+ hepatocytes in the portal vein triad region are low in quantity but can be activated, apparently, upon PH or chronic liver injury; a portion of hepatocytes surrounding the portal vein can directly differentiate into biliary cells; Sox9+/HNF4α+ hybrid hepatocytes are located near the branches of the portal vein and terminal biliary tract and can become hepatocytes and BECs after liver injury; Lgr5+ pericentral hepatocytes have a long life and contribute to the homeostasis of the liver; hepatocytes marked by telomerase expression are the main source of hepatocytes in normal liver homeostasis and injury-induced LR.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750