Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts

Jiaxin Guan; Lu Gan; Di Jin; Xiaowei Wu; Luyang Cheng; Meiling Liu; Ying Fan; Jing Zhou; Hanlu Zhang; Yina Zhang; Ping Zhou

doi:10.12659/MSM.929170

20 April 2021 : Clinical Research

Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts

Jiaxin Guan^1BCEF, Lu Gan^1B, Di Jin^1ACD, Xiaowei Wu^1B, Luyang Cheng^1C, Meiling Liu^1C, Ying Fan^1B, Jing Zhou^2B, Hanlu Zhang^1B, Yina Zhang^1AFG*, Ping Zhou^1FG

DOI: 10.12659/MSM.929170

Med Sci Monit 2021; 27:e929170

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Figure 1 The relative expression levels of circRNAs. (A–D) The relative expression levels (ΔCT) of hsa_circ_0021739, hsa_circ_0019693, hsa_circ_0013121, and hsa_circ_0002332 in the postmenopausal osteoporosis group (PMOP; n=28) and healthy postmenopausal group (control; n = 25). (E) Differences (fold change) in RNA-sequencing (RNA-seq) and reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR) results (2−ΔΔCT).

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Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts

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