Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts

Jiaxin Guan; Lu Gan; Di Jin; Xiaowei Wu; Luyang Cheng; Meiling Liu; Ying Fan; Jing Zhou; Hanlu Zhang; Yina Zhang; Ping Zhou

doi:10.12659/MSM.929170

20 April 2021 : Clinical Research

Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts

Jiaxin Guan^1BCEF, Lu Gan^1B, Di Jin^1ACD, Xiaowei Wu^1B, Luyang Cheng^1C, Meiling Liu^1C, Ying Fan^1B, Jing Zhou^2B, Hanlu Zhang^1B, Yina Zhang^1AFG*, Ping Zhou^1FG

DOI: 10.12659/MSM.929170

Med Sci Monit 2021; 27:e929170

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Figure 2 Correlation between hsa_circ_0021739 expression and clinical characteristics of patients with postmenopausal osteoporosis (PMOP). (A–C) Correlation between hsa_circ_0021739 expression and T-scores for the lumbar vertebra, femur, and forearm. (D) Receiver-operating characteristic (ROC) curve for hsa_circ_0021739 expression in peripheral blood mononuclear cells (PBMCs) of PMOP patients (area under the curve [AUC]: 0.849, confidence interval [CI]: 0.724–0.932, P<0.001).

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Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts

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