Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts

Jiaxin Guan; Lu Gan; Di Jin; Xiaowei Wu; Luyang Cheng; Meiling Liu; Ying Fan; Jing Zhou; Hanlu Zhang; Yina Zhang; Ping Zhou

doi:10.12659/MSM.929170

20 April 2021 : Clinical Research

Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts

Jiaxin Guan^1BCEF, Lu Gan^1B, Di Jin^1ACD, Xiaowei Wu^1B, Luyang Cheng^1C, Meiling Liu^1C, Ying Fan^1B, Jing Zhou^2B, Hanlu Zhang^1B, Yina Zhang^1AFG*, Ping Zhou^1FG

DOI: 10.12659/MSM.929170

Med Sci Monit 2021; 27:e929170

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Figure 3 Tartrate-resistant acid phosphatase (TRAP) staining of osteoclasts in different groups (magnification, ×400). (A) Control group exposed to phosphate-buffered saline (PBS). (B) Cells exposed to receptor activator of nuclear factor (NF)-κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) for osteoclast induction. (C) Empty vector group exposed to RANKL and M-CSF. (D) hsa_circ_0021739 overexpression group exposed to RANKL and M-CSF. (E) Microscopic images showing cell morphology and numbers of TRAP-positive cells. *** P<0.0001.

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Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts

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