Se-Methylselenocysteine Alleviates Liver Injury in Diethylnitrosamine (DEN)-Induced Hepatocellular Carcinoma Rat Model by Reducing Liver Enzymes, Inhibiting Angiogenesis, and Suppressing Nitric Oxide (NO)/Nitric Oxide Synthase (NOS) Signaling Pathway

Jun Ding; Chuang Qi; Jinmao Li; Chuying Huang; Jiayao Zhang; Yong Zhang; Yi Li; Bin Fan

doi:10.12659/MSM.929255

04 August 2021 : Animal Research

Se-Methylselenocysteine Alleviates Liver Injury in Diethylnitrosamine (DEN)-Induced Hepatocellular Carcinoma Rat Model by Reducing Liver Enzymes, Inhibiting Angiogenesis, and Suppressing Nitric Oxide (NO)/Nitric Oxide Synthase (NOS) Signaling Pathway

Jun Ding^1ABCDEFG*, Chuang Qi^2BCDEF, Jinmao Li^1BCDF, Chuying Huang^2BCD, Jiayao Zhang^1BCF, Yong Zhang^1BC, Yi Li^1BCF, Bin Fan^1CF

DOI: 10.12659/MSM.929255

Med Sci Monit 2021; 27:e929255

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Figure 6 Effects of se-methylselenocysteine (MSC) treatments on vascular endothelial growth factor (VEGF) expression in liver tissues of rats in different groups. (A) Immunohistochemical analysis for evaluating VEGF expression. The scale bars of 200 μm are illustrated in images. (B) RT-PCR assay for assessing VEGF gene transcription. # P<0.05 vs Normal control group. * P<0.05 vs Model group.

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Se-Methylselenocysteine Alleviates Liver Injury in Diethylnitrosamine (DEN)-Induced Hepatocellular Carcinoma Rat Model by Reducing Liver Enzymes, Inhibiting Angiogenesis, and Suppressing Nitric Oxide (NO)/Nitric Oxide Synthase (NOS) Signaling Pathway

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